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Monoclonal Antibodies Against Human MS4A4A

Tech ID #: 345.3A CONNECT WITH A MANAGER FOR LICENSING

Description of Technology

University of Calgary researcher, Dr. Julie Deans, has produced three monoclonal antibodies (mouse IgG1) against human MS4A4A. MS4A4A is a member of the MS4A family, expressed exclusively in monocytes and M2 macrophages. Importantly, MS4A4A has been shown to be overexpressed in multiple myeloma, suggesting a potential role as a biomarker and/or therapeutic target in these diseases.   The anti-MS4A4A antibodies generated by Dr. Deans could be valuable for both pre-clinical and clinical research applications. These particular antibodies were generated against extracellular epitopes, have no observed cross-reactivity, and have been used successfully for flow cytometry and immunoprecipitation. 

Figure 1 

Figure 1: Specificity of MS4A4A antibodies (5C12, 4H2, 3F2) was evaluated by flow cytometry (anti-MS4A4A in red; controls in blue, green and orange) in BJAB-MS4A4A-HA cells

Figure 2 

Figure 2: Specificity of MS4A4A antibodies (5C12, 4H2, 3F2) was evaluated by immunoprecipitation from BJAB-MS4A4A-HA cells with the antibodies indicated (left panel) and immunoblotting using anti-HA (right panel)

Areas of Application
  • Inflammation and immunology
  • Oncology - multiple myeloma
Competitive Advantages
  • Extremely specific
  • Well characterized
  • Known applications (IP, FC)
  • Binds to extracellular domain
  • No need to permeabilize cells