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  • Agriculture & Veterinary Medicine
    • A Natural Source Red Pigment

      A Natural Source Red Pigment

      A natural source red pigment with strong and stable color. The pigment appears unique and suitable for food and cosmetic industry use.

    Agriculture & Veterinary Medicine

  • Energy, Cleantech & Environmental

    Energy, Cleantech & Environmental

  • Engineering & Physical Sciences

    Engineering & Physical Sciences

  • Laboratory Research Tools & Reagents
    • Antibodies
      • CDF-4 Anti-Golgin Antibodies

        CDF-4 Anti-Golgin Antibodies

        The Golgi complex is composed of a stack of membrane-bound cisternae located in the cytoplasm adjacent to the nucleus.  The Golgi processes newly synthesized proteins (post-translational modification), sorts and routes them to their final destination.  At the outer surface of this complex or trans Golgi, vesicles containing modified proteins leave the Golgi.

        Researchers at the University of Calgary have developed and tested a monoclonal antibody that detects a component of the “trans” compartment of the Golgi apparatus.  This molecular biological tool can be used to detect the Golgi complex in a wide variety of cells including tissue culture cells such as HeLa cells, and HEp-2 cells, specialized cells (i.e. spermatids) and archived tissues. This antibody can be used as a reference marker in serological examination of patients diagnosed with Sjogren’s syndrome and other systemic autoimmune rheumatic diseases.  A large number of patients with anti-Golgi antibodies, particularly golgin97, have Sjogren’s syndrome.

      • EEA1 Monoclonal Antibodies

        EEA1 Monoclonal Antibodies

        Endocytosis is an important cellular process involved in many facets of cellular function, such as proliferative signaling, neuronal transmission, and the uptake of nutrients.  This process relies on the fusion of endocytic vesicles with early endosomes.  Early endosomes are responsible for sorting these events and recycling many of the plasma membrane associated receptors. The early endosomal antigen 1 (EEA1) protein, which is present on early endosomes, is involved in vesicle fusion during endocytosis.  In neurons, early endosomes are involved in recycling of neurotransmitter receptors, a necessary process in neuron to neuron signaling. Clinically, autoantibodies to EEA1 it have been detected in some patients with neurological deficits.  Moreover, autoantibodies to EEA1 were found to enhance excitatory synaptic transmission which may account, in part, for the neuropathies observed in patients with these autoantibodies.

        Researchers at the University of Calgary have developed and tested mouse monoclonal antibodies that specifically bind to the human EEA1 protein.  These antibodies can be utilized to detect the early endosomes by indirect immunofluorescence, immunohistochemistry, immunoprecipitation, and by Western blot analysis in both neuronal and non-neuronal cell types.

      • Monoclonal Antibodies Against Human MS4A4A

        Monoclonal Antibodies Against Human MS4A4A

      • Monoclonal Antibodies for Detection of GWBs

        Monoclonal Antibodies for Detection of GWBs

        GW bodies (GWBs, also known as mammalian P bodies) influence the expression and fate of mRNA, and thus the overall cellular mRNA profile. They are involved in the storage, transport and degradation of a subset of mRNA. GWBs are also linked to the RNA interference (RNAi) pathway resulting in either mRNA decay and/or translational repression.

        Researchers at the University of Calgary have developed mouse monoclonal antibodies that specifically bind the GW182 protein, a mRNA binding protein within GWBs. These antibodies can be utilized to detect the GW182 protein and GWBs by indirect immunofluorescence, immunohistochemistry, immunoprecipitation, and by Western blot analysis. These monoclonal antibodies can be used as reference markers to validate the presence of autoantibodies to GWBs in patients with motor/sensory neuropathy, Sjögren’s syndrome and systemic lupus erythematosus (SLE).

      • Monoclonal Antibodies to ING1 Isoforms

        Monoclonal Antibodies to ING1 Isoforms

        The ING genes encode a family of at least seven proteins with conserved plant homeodomain (PHD)-type zinc fingers in their C-termini. The founding member, ING1, is capable of binding to and affecting the activity of histone acetyltransferase (HAT), histone deacetylase (HDAC), and factor acetyltransferase (FAT) protein complexes. Upon UV irradiation, ING1 and ING2 bind stress induced signaling phospholipids such as phosphatidylinositol 5-monophosphate and cause cell cycle arrest.  ING1b interacts with proliferating cell nuclear antigen to promote DNA repair or induce apoptosis in cells to prevent tumorigenesis, depending upon the severity of DNA damage. ING proteins, which are down-regulated in a broad variety of cancer types, are able to restrict cell growth and proliferation, induce apoptosis, and modulate cell cycle progression, which strongly supports the notion that ING family proteins act as type II tumor suppressors.  The ING proteins regulate chromatin structure through specific binding to histones H3 and H4 via their plant homeodomains (PHDs) and recruitment of HAT & HDAC complexes to particular regions of chromatin, thus playing central roles in reading of the "histone code".

        Researchers at the University of Calgary have developed a panel of nine monoclonal antibodies (MAbs) against human and rodent ING1 proteins that specifically recognize the p33ING1b, p47ING1a and p24ING1c isoforms of ING1.

      • Monoclonal Antibody Against Human MS4A8B

        Monoclonal Antibody Against Human MS4A8B

      • Polyclonal Antibodies Against Human CD20

        Polyclonal Antibodies Against Human CD20

      Antibodies

    • Research Tools

      Research Tools

    • Cell Lines Expressing Calcium Channel and Genetically-Encoded Calcium Indicators

      Cell Lines Expressing Calcium Channel and Genetically-Encoded Calcium Indicators

      Voltage-gated calcium channels are important conduits for the entry of Ca2+ into numerous cell types, and consequently are major therapeutic targets for several disease states linked to ion channels. Conventional electrophysiological approaches used to study ion channels present many challenges that impede novel research and drug discoveries.

    • Novel Peptide Suppress Cava28 Subnit Function to Reduce Inflammatory and Neuropathic Pain

      Novel Peptide Suppress Cava28 Subnit Function to Reduce Inflammatory and Neuropathic Pain

      The global market for pain management is more than $7 billion annually, representing a huge opportunity for products which displace the use of opioids as a first line of treatment.

    Laboratory Research Tools & Reagents

  • Life & Medical Sciences
    • Diagnostics
      • A Serum-Based Diagnostic Test to Identify Pediatric Septic Shock

        A Serum-Based Diagnostic Test to Identify Pediatric Septic Shock

        Prompt detection of septic shock in pediatric patients thereby reducing the mortality rates of patients.

      • Novel Planar Microelectrodes with Unique Morphological Structure for Enhanced Neural Recording

        Novel Planar Microelectrodes with Unique Morphological Structure for Enhanced Neural Recording

      • PCR-based Diagnostic for Detection of Lyme Disease Bacteria

        PCR-based Diagnostic for Detection of Lyme Disease Bacteria

        Lyme disease is the most common tick-borne disease in North America, and is transmitted by blacklegged ticks carrying Borrelia bacteria.  Infection by a tick takes at least 24 hours because of the time required for the bacteria to travel from the tick midgut to its salivary glands. Prompt removal and detection of ticks is the primary method for reducing infection; however, ~300,000 people are still infected with Lyme disease each year in the US alone.

        The bacteria responsible for causing Lyme disease are members of the genus Borrelia, with 12 of the 36 known Borrelia species causing Lyme disease.  Furthermore, the number of ticks infected with Borrelia bacteria is estimated to be increasing by 2.5% annually.  Routine surveillance uses PCR testing on ticks to determine if they carry Borrelia burgdorferi, which is the most common species found in North America; however, new species have been detected and a shift in strain prevalence due to climate changes and regional restrictions of tick travel is expected to continue occurring. 

      Diagnostics

    • Medical Devices
      • Integrated Neonatal Support with Placental Transfusion and Resuscitation (INSPIRE)

        Integrated Neonatal Support with Placental Transfusion and Resuscitation (INSPIRE)

        Current international guidelines for the management of infants at birth suggest that there be a delay before the umbilical cord is clamped, this may confer benefit by improving cardiovascular function and postnatal adaptation. Studies show that remaining connected to the umbilical cord for one to three minutes after birth reduces the risk of bleeding in the brain by as much as fifty per cent. The standard care for health newborns is to wait at least one minute after birth before cutting the umbilical cord.

      • Pneumothorax Drainage Device

        Pneumothorax Drainage Device

        Spontaneous pneumothorax is a significant global health problem with an estimated incidence of up to two million events per year globally. Air in the chest cavity can sometimes resolve itself but often requires a hospital admission and more importantly, lifesaving urgent medical care. In a military combat setting, about thirteen per cent of penetrating wounds to the thoracic cavity require thoracic intervention including a chest tube, contributing up to thirty per cent of combat deaths.

      • Trans-esophageal Aortic Compression Balloon

        Trans-esophageal Aortic Compression Balloon

        Massive blood loss from severe abdominal or distal limb trauma is challenging to control and necessitates surgical intervention. Current therapies rely on blood replacement products which can be difficult to obtain and may lead to complications for the patient. The trans-esophageal aortic compression balloon works to control blood loss, reducing the need to replace lost blood.

      Medical Devices

    • Therapeutics
      • Novel cyclodextrin-based excipients for drug formulations

        Novel cyclodextrin-based excipients for drug formulations

        Cyclodextrins (CDs) are cyclic oligosaccharides used for the improvement of water-solubility and bioavailability of medicinal products. At least six types are available on the market. This class of excipients can be readily tailored for use in drug formulations.

      • Novel Nucleoside-based Antiprotozoan Drugs

        Novel Nucleoside-based Antiprotozoan Drugs

        Infectious diseases caused by parasites are a serious global health problem with significant rates of morbidity and mortality. Due to the emergence of treatment-resistant strains of many pathogens, there is a clear need for novel approaches to infectious disease treatment.

      • Novel Proteins with Anti-bacterial and Anti-eukaryotic Activity

        Novel Proteins with Anti-bacterial and Anti-eukaryotic Activity

      • Therapeutic Application of AlphaB-cystallin Promotes Recovery from Peripheral Nerve Injury

        Therapeutic Application of AlphaB-cystallin Promotes Recovery from Peripheral Nerve Injury

        Damage to peripheral nerves often lead to dysfunction of hands, arms and legs because nerve fibers do not regrow completely in humans. Despite being a common injury, current treatment options rely on surgical anastomosis or nerve engraftment often leading to non-optimal outcomes. Moreover, adequate time for a surgery is often missed as surgical treatment decisions are made later after an initial diagnosis of the injury. An effective treatment option is needed for peripheral nerve injury as delayed surgical repair can result in only partial nerve regeneration.

        AlphaB-crystallin (HSPB5/CRYAB/αBC) is a small heat shock protein that enhances survival in response to stress by inhibiting protein aggregation, reducing levels of intracellular reactive oxygen species and inhibiting programmed cell death. αBC is constitutively expressed by the peripheral nervous system (PNS) axons and Schwann cells. The inventors discovered that loss of the crystallin impaired conduction velocity as well as motor and sensory functions were likely related to deficits in remyelination. Intravenous injections of recombinant human αBC promoted remyelination and functional recovery in wild-type mice following a sciatic nerve crush injury revealing a therapeutic effect of αBC.

      Therapeutics

    • The Mild Behavioral Impairment Checklist (MBI-C)

      The Mild Behavioral Impairment Checklist (MBI-C)

      The emergence of neuropsychiatric symptoms in older adults may provide an indicator of early neurodegenerative disease and dementia. The syndrome Mild Behavioral Impairment (MBI) describes the relationship between later-life onset of sustained neuropsychiatric symptoms and changes in behavior and personality, and the risk of cognitive decline and dementia. The International Society to Advance Alzheimer’s Research and Treatment - Alzheimer’s Association (ISTAART-AA) diagnostic criteria for MBI were published in Alzheimer's & Dementia (Ismail, et al., 2016).

    Life & Medical Sciences

  • Manufacturing & Industrial Application

    Manufacturing & Industrial Application

  • Other
    • Medical Training Devices
      • Soiled Airway Trainer

        Soiled Airway Trainer

        Approximately twenty-five per cent of pre-hospital trauma cases require airway management by emergency response personnel, and delays in proper airway management are a common cause of preventable death in pre-hospital and emergency settings. If performed improperly, airway management procedures can cause secondary injuries to patients. Training emergency personnel to effectively manage a patient's airway is vital for patient safety and optimal treatment conditions.

      Medical Training Devices

    • Womba Musical Instrument

      Womba Musical Instrument

      Empowering a child's physical and psychological development through in utero movement, artistic expression and parental bonding.

    Other

  • Social & Clinical Innovation

    Social & Clinical Innovation

RBC Social Enterprise Accelerator Demo Day

Inaugural RBC Social Enterprise Accelerator a resounding success

A mobile escape room, recycled denim yoga mats and science education. These are a few of the offerings from the wide range of startups who participated as part of the first RBC Social Enterprise Accelerator Program, delivered by Innovate Calgary. A demo day held on June 13 saw the companies pitch their products and services to RBC executives, investors, potential customers and high profile entrepreneurs from the Calgary community.

"Social entrepreneurs are innovative game changers, focused on creating businesses that blend sustainability, profitability and social impact,” says Jeff Boyd, Regional President, RBC. “We believe we have a role to play in creating an environment where social enterprise can thrive and that’s why we are thrilled to partner with Innovate Calgary and support the RBC Social Enterprise Accelerator.”

Each participating startup was matched with a business advisor from the startup community within Calgary’s innovation ecosystem. These mentors bring decades of business, technical, and entrepreneurial experience to the accelerator and help address specific business challenges, with the goal of increasing impact and growing revenue.

“At the start of the program, most of the entrepreneurs have a very clear understanding about the social impact they are creating but weren’t aware of how to turn it into a viable, profitable business,” says Peter Garrett, president of Innovate Calgary. “That’s fundamentally what this program is about – creating viable, businesses that have that strong social impact. It is important to come together and help these companies build, grow and deliver their social mandates.”

RBC will continue to champion social enterprise and innovation with support for a second accelerator, planned for the fall.

Additional quotes:
“This was such an amazing afternoon. To see the progress that has been made in such a short time is outstanding. I am so proud to see this vision come to life when we see what these folks are doing in these accelerator programs and making such an impact.”
Andrew McNair, Regional Vice President, RBC

“At the beginning of this program, we did not have a mobile unit, waivers, a business licence, liability insurance, or much website traffic from our education market. Now here we are today with over 1700 participants, 11,000 views of our informational video, excited returning customers and new inquiries. We hope to go from 10 to 75 schools next year and implement this across Canada.”
Paul Harvey and Eric Reynolds, Mobile Escape

“Using our mindfulness platform, we hope to transform post-traumatic stress to post-traumatic success in the workplace. Currently there isn’t much being done in mental health prevention in the workplace. In the accelerator program, we focused on the path to commercialization and our train the trainer platform, speaking to groups like Calgary Fire Department to build culture and to U of C to provide training at a post-secondary level.”
Derek Luk, Mindful Mental Training

“When I joined the accelerator about seven months ago, we were trying to figure out the coating on our machine washable, recycled denim yoga mat. Since then, we’ve expanded our product line to include meditation pillows. We have received the green light to employ at-risk women from the Calgary Dream Centre to teach a skill. Providing a vocation is a huge developmental factor in people who are recovering. It’s not just about yoga mats, it is about sustainable markets and sustainable labour.”
Zachary Champoux, Nomad EcoProducts

“We started out in this program wanting to learn about business planning, IP and legal and with all the support, we are on our way to having a trademark and implementing our business model canvas. We provide a program specifically for young men. It gives them a place to have a conversation on what it is like to be a boy and man in society today. It gives them a place to be safe and ask for support. Our dream is to create a training institute and take this across Canada and provide this program to boys within their local area. We can provide a very strong curriculum and evidence and research to support the program. We know this could greatly impact society.”
Pam Krause, Calgary Sexual Health Centre – The WiseGuyz program

“We need kids to be creators of technology, not just users and consumers of technology. Sustainable changes are about getting kids engaged by prototyping and problem solving; but also getting to those who teach those kids and help them engage more learners in more ways.”
Gina Cherkowski, STEM Learning Lab

“Our goal and mission is working toward zero waste events and we envision a future that can be zero waste and providing a solution. With advice from the program we launched a new website and we hope to bring this across Canada to provide a single point of contact for event waste management.”
Colin Smith, Green Event Services

“Through the program I concentrated on documenting my process, automating certain aspects and started applying for funding through Alberta Innovates Technology Futures. Now I’m looking to connect with even more families who need service.”
Sue Crawford, Enable

Background

What is the RBC Social Enterprise Accelerator?
The RBC Social Enterprise Accelerator (SEA), a six-month program for Calgary-based startups for whom the combination of social impact and profitability is core to their mission and business model. Innovate Calgary, delivers the program that focuses on accelerating impact, profitability and technology. There is no cost for participants as SEA is generously supported by RBC.

Participants are assigned an experienced executive or entrepreneur as a mentor, who also understands social impact. The mentor helps to address specific business challenges, mature their business model and technology, create increased impact and grow revenue. Participants also receive pitch coaching and expert advice to build their operational backbone in the areas of legal, accounting, and marketing strategy.

Who are the participating companies?
Pam Krause and Debb Hurlock, Calgary Sexual Health Centre – The WiseGuyz program
WiseGuyz engages junior high boys in a weekly program that has four modules: human rights, sexual health, gender, and positive relationships. The program addresses issues young men face to give them tools to engage in healthy relationships; understand the connection between masculinity and male norms, sexuality and violence; and provides targeted education, skills development, and support to help young men achieve sexual well-being and healthy relationships.
www.calgarysexualhealth.ca

Sue Crawford, Enable
Enable is an online matchmaking platform that partners families and people affected by disability, to reliable student caregivers. By creating meaningful partnerships between people, and connecting with accessible businesses, Enable fosters a stronger sense of belonging for people of all abilities within communities.
http://enablecommunity.ca/

Colin Smith, Green Event Services
Green Event Services provides equipment for responsible event waste management. The company delivers recycling stations to events and helps to manage waste reduction by creating a recycling plan with staff and volunteers.
www.greeneventservices.ca

Derek Luk, Mindful Mental Training
Mindfulness is a form of attention and awareness training cultivated through meditation. The company’s focus is mental health prevention by providing Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT) in an online platform. The platform hopes to remove barriers that prevent people from accessing clinically supported mindfulness-based interventions, with the ultimate goal of preventing suicides.
http://mindfulmentaltraining.ca

Paul Harvey and Eric Reynolds, Mobile Escape
Mobile Escape exists to awaken the senses by bringing people together to think differently about the world around them. The company creates an immersive experience through the concept of an escape rooms, where participants are put within a real-life scenario, solve puzzles to eventually escape the room.
www.mobileescape.ca

Zachary Champoux, Nomad EcoProducts
Nomad EcoProducts manufactures all of their products, primarily yoga mats and meditation cushions, from recycled materials with the aim to divert materials from landfills and lower GHG emissions in the atmosphere.
http://nomad.gives/

Gina Cherkowski, STEM Learning Lab
STEM Learning Lab engages teachers and students in high quality, hands-on STEM (science, technology, engineering and math), STEAM (STEM + Art) and Maker learning experiences. The company offers educational programs for teachers as well as innovative and fun programs for youth.
www.stemlearninglab.com

Who are the mentors?
Jill Andres, Creating Value Inc.
Craig Elias, Bow Valley College
Peter Fenwick, Fenwick & Associates
Kari Gordon, Startup Calgary
Jim Gibson, Rainforest Alberta
Leighton Healy, Bootkik
Sarah Lewis, Bow Valley College
Houston Peschl, Haskayne School of Business
Allison Swelin, Garmin
Kevin Franco, Innovate Calgary
Scott Pickard

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